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Structural MR brain imaging is important in the understanding of regional brain changes in healthy aging and in disease processes. Current methods are often labour-intensive, requiring hours of manual tracing. SABRE (Semi-automatic Brain Region Extraction) is a new technique that allows rapid and reliable parcellation of cortical and subcortical brain regions. Utilization of SABRE in conjunction with a validated tissue-compartment segmentation program [1] can provide measures of gray matter, white matter, ventricular CSF, and sulcal CSF measures for designated brain regions. We present data showing high inter-rater reliably for all regions, with correlations between 0.95 – 0.99. Regional tissue measures of healthy young and healthy older adults were also examined, demonstrating the sensitivity of this protocol to brain volume changes that occur with aging.

SABRE: A Time Efficient Semi-automated Regional Parcellation Method for Structural Magnetic Resonance Brain Images