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Motion correction in fMRI time series is essential for accurate statistical analyses. Typically motion correction is applied in a rigid fashion between time series volumes. Such corrections assume no relative motion between slices. An improved motion correction scheme, map-slice-to-volume (MSV), was developed previously using mutual information (MI) to register individual fMRI slices onto an anatomical volume to account for inter-slice motion [6]. As each slice’s orientation represents a statistically independent sampling of the patient’s motion at multiple intervals throughout the acquisition, a smoothed estimate of the patient’s trajectory in time can be computed by jointly estimating each slice’s orientation while minimizing the implied acceleration of the patient’s head subject to applying a priori, slice-related weights based on known registration reliabilities. The results of this joint mapping of slices into a volume (JMSV) show further substantial improvement in slice registration and subsequent motion estimation.

Improved Motion Correction in fMRI by Joint Mapping of Slices into an Anatomical Volume