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A method fully utilizing multiscale line filter responses is pre- sented to estimate the point spread function (PSF) of a CT scanner and diameters of small tubular structures based on the PSF. The estimation problem is formulated as a least square fitting of a sequence of multiscale responses obtained at each medial axis point to the precomputed multi- scale response curve for the ideal line model. The method was validated through phantom experiments and demonstrated to accurately measure small-diameter structures which are significantly overestimated by con- ventional methods based on the full width half maximum (FWHM) and zero-crossing edge detection.

Accurate Quantification of Small-Diameter Tubular Structures in Isotropic CT Volume Data Based on Multiscale Line Filter Responses