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In this paper, we introduce a technique for super-resolution reconstruction of diffusion MRI, harnessing fiber-continuity (FC) as a constraint in a global whole-brain optimization framework. FC is a biologically-motivated constraint that relates orientation information between neighboring voxels. We show that it can be used to effectively constrain the inverse problem of recovering high-resolution data from low-resolution data. Since voxels are inter-related by FC, we devise a global optimization framework that allows solutions pertaining to all voxels to be solved simultaneously. We demonstrate that the proposed super-resolution framework is effective for diffusion MRI data of a glioma patient, a healthy subject, and a macaque.

Globally Optimized Super-Resolution of Diffusion MRI Data via Fiber Continuity