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Biological networks are a very convenient modeling and visualization tool to discover knowledge from modern high-throughput genomics and post-genomics data sets. Indeed, biological entities are not isolated but are components of complex multilevel systems. We go one step further and advocate for the consideration of causal representations of the interactions in living systems. We present the causal formalism and bring it out in the context of biological networks, when the data is observational. We also discuss its ability to decipher the causal information flow as observed in gene expression. We also illustrate our exploration by experiments on small simulated networks as well as on a real biological data set.

Causal Queries from Observational Data in Biological Systems via Bayesian Networks: An Empirical Study in Small Networks