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Multi-site electron paramagnetic resonance (EPR) oximetry, using multi-probe implantable resonators, was used to measure the partial pressure of oxygen (pO(2)) in the brains of rats following normobaric hyperoxia and mild hypoxia. The cerebral tissue pO(2) was measured simultaneously in the cerebral cortex and striatum in the same rats before, during, and after normobaric hyperoxia and mild hypoxia challenges. The mean baseline tissue pO(2) values were not significantly different between the cortex and striatum.During 30 min of 100% O(2) inhalation, a statistically significant increase in tissue pO(2) of all four sites was observed, however, the tissue pO(2) of the striatum area was significantly higher than in the forelimb area of the cortex. Brain pO(2) significantly decreased from the baseline value during 15 min of 15% O(2) challenge.No differences in the recovery of the cerebral cortex and striatum pO(2) were observed when the rats were allowed to breathe 30% O(2). It appears that EPR oximetry using implantable resonators can provide information on pO(2) under the experimental conditions needed for such a study. The levels of pO(2) that occurred in these experiments are readily resolvable by multi-site EPR oximetry with multi-probe resonators. In addition, the ability to simultaneously measure the pO(2) in several areas of the brain provides important information that could potentially help differentiate the pO(2) changes that can occur due to global or local mechanisms.

advances in experimental medicine and biology

Cerebral Oxygenation of the Cortex and Striatum Following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable Resonators