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This chapter aims to provide an introduction to how engineering tools in general and computational models in particular can contribute to advancing the tissue engineering (TE) field. After a description of the current state of the art of TE, the developmental engineering paradigm is briefly discussed. Subsequently an overview is provided of different model categories that focus on different aspects of TE. These categories consists of the models that focus on either the TE product, the TE process or the in vivo results obtained after implantation. Generally, in all these models the aim is firstly to understand the biological process at hand and secondly to design strategies in silico to enhance the desired in vitro or in vivo behaviour. Finally, the need for quantification and parameter determination is discussed along with the computational tools and models that can be used to design the thereto required experiments in the most intelligent way.

In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering