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The minimum description length (MDL) principle states that the best model toaccount for some data minimizes the sum of the lengths, in bits, of thedescriptions of the model and the residual error. The description length isthus a criterion for model selection. Description-length analysis of HLAalleles from the Chicago MACS cohort enables classification of allelesassociated with plasma HIV RNA, an indicator of infection progression.Progression variation is most strongly associated with HLA-B. Individualswithout B58s supertype alleles average viral RNA levels 3.6-fold greater thanindividuals with them.Comment: 17 pages, 1 figur

HLA and HIV Infection Progression: Application of the Minimum Description Length Principle to Statistical Genetics