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For gray-value based multi-modality registration the similarity measure is essential. Excellent results have been obtained with mutual information for various modality combinations. In this contribution we consider local correlation as similarity measure for multi-modality registration. Using a software phantom it is analyzed why local correlation is suitable for this registration task whereas direct gray-value correlation itself is usually not. It is shown that registration with local correlation can be done using only a fraction of the image volume offering an opportunity to accelerate the algorithm. Within validation, registration of the phantom images, two simultaneously acquired dual contrast MR images, and a clinical CT-MR data set has been studied. For comparison, the data sets have also been registered with mutual information. The results show that not only mutual information, but also local correlation is suitable for gray-value based multi-modality registration.

Gray-Value Based Registration of CT and MR Images by Maximization of Local Correlation