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MRI is unique in its ability to non-invasively and selectively alter tissue magnetization, and create tagged patterns within a deforming body such as the heart muscle. The resulting grid patterns define non-invasive tissue markers, providing a mechanism for in-vivo measurement of tissue motion and strain. In this paper, we report on objective comparison of thin-plate spline warps in reconstructing true deformations when using homologous land-mark points and when using homologous curves from tagged MR-image sequences of a cardiac motion simulator. In addition, the number of corresponding land-mark points as well as the number of corresponding curves are varied in order to determine the effect on accuracy of reconstructions. Finally, application of the developed techniques to computing LV tissue motion and strain in systole from short-axis tagged images of a porcine model with anterior myocardial infarction (MI) are given.

Comparison of Land-Mark-Based and Curve-Based Thin-Plate Warps for Analysis of Left-Ventricular Motion from Tagged MRI