Open AccessState‐of‐play for cellular therapies in cardiac repair and regeneration
Author(s) -
Vaka Ramana,
Davis Darryl R.
Publication year - 2021
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.3446
Subject(s) - biology , regeneration (biology) , context (archaeology) , paracrine signalling , disease , clinical trial , neuroscience , bioinformatics , intensive care medicine , pathology , microbiology and biotechnology , medicine , paleontology , receptor , biochemistry
Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state‐of‐play” of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ongoing clinical trials. Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of long‐term cardiac engraftment. This discussion informs on promising new approaches to indicate future avenues for the field.