Open AccessEpigenetic regulation of neural stem cells: The emerging role of nucleoporins
Author(s) -
Colussi Claudia,
Grassi Claudio
Publication year - 2021
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.3444
Subject(s) - nucleoporin , biology , epigenetics , neurogenesis , nuclear pore , chromatin , neural stem cell , embryonic stem cell , neuroscience , microbiology and biotechnology , stem cell , genetics , gene , nucleus , cell nucleus , nuclear transport
Nucleoporins (Nups) are components of the nuclear pore complex that, besides regulating nucleus‐cytoplasmic transport, emerged as a hub for chromatin interaction and gene expression modulation. Specifically, Nups act in a dynamic manner both at specific gene level and in the topological organization of chromatin domains. As such, they play a fundamental role during development and determination of stemness/differentiation balance in stem cells. An increasing number of reports indicate the implication of Nups in many central nervous system functions with great impact on neurogenesis, neurophysiology, and neurological disorders. Nevertheless, the role of Nup‐mediated epigenetic regulation in embryonic and adult neural stem cells (NSCs) is a field largely unexplored and the comprehension of their mechanisms of action is only beginning to be unveiled. After a brief overview of epigenetic mechanisms, we will present and discuss the emerging role of Nups as new effectors of neuroepigenetics and as dynamic platform for chromatin function with specific reference to the biology of NSCs.