Open AccessConcise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
Author(s) -
Desai Amar,
Yan Yan,
Gerson Stanton L.
Publication year - 2019
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.18-0123
Subject(s) - cancer stem cell , stem cell , cancer research , metastasis , biology , translational medicine , cancer , medicine , bioinformatics , pathology , genetics
Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self‐renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. S tem C ells T ranslational M edicine 2019;8:75–81