Open AccessConcise Review: The Deleterious Effects of Cigarette Smoking and Nicotine Usage and Mesenchymal Stem Cell Function and Implications for Cell‐Based Therapies
Author(s) -
Greenberg Jordan M.,
Carballosa Carlos M.,
Cheung Herman S.
Publication year - 2017
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.17-0060
Subject(s) - mesenchymal stem cell , nicotine , cigarette smoke , stem cell , medicine , cell , regenerative medicine , bioinformatics , biology , immunology , pharmacology , microbiology and biotechnology , environmental health , pathology , genetics
Stem cell sources for cell‐based therapeutics are often screened for infectious agents and genetic diseases prior to implantation; however, there are other risk factors that are often overlooked, which may ultimately lead to less efficacious clinical outcomes. One such risk factor is exposure of mesenchymal stem cells (MSCs) to cigarette smoke or nicotine. Recent data have shown that exposure to cigarette smoke or nicotine leads to decreased regenerative potential, namely decreased proliferation, decreased migration, and decreased differentiation potential of exposed MSCs. This review provides a brief introduction into MSCs and their respective niches and a summary regarding the interactions of cigarettes and nicotine with MSCs populations. Specifically, the effects of cigarette smoke and nicotine on the regenerative potential of MSCs (i.e., proliferation, migration, and differentiation) will be covered with an emphasis on considerations for the development of future cell‐based clinical trials and therapies. Stem Cells Translational Medicine 2017;6:1815–1821