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Purpose  To develop and evaluate a method for rapid estimation of multiparametric T 1 , T 2 , proton density, and inversion efficiency maps from 3D‐quantification using an interleaved Look‐Locker acquisition sequence with T 2  preparation pulse (3D‐QALAS) measurements using self‐supervised learning (SSL) without the need for an external dictionary.    Methods  An SSL‐based QALAS mapping method (SSL‐QALAS) was developed for rapid and dictionary‐free estimation of multiparametric maps from 3D‐QALAS measurements. The accuracy of the reconstructed quantitative maps using dictionary matching and SSL‐QALAS was evaluated by comparing the estimated T 1  and T 2  values with those obtained from the reference methods on an International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology phantom. The SSL‐QALAS and the dictionary‐matching methods were also compared in vivo, and generalizability was evaluated by comparing the scan‐specific, pre‐trained, and transfer learning models.    Results  Phantom experiments showed that both the dictionary‐matching and SSL‐QALAS methods produced T 1  and T 2  estimates that had a strong linear agreement with the reference values in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology phantom. Further, SSL‐QALAS showed similar performance with dictionary matching in reconstructing the T 1 , T 2 , proton density, and inversion efficiency maps on in vivo data. Rapid reconstruction of multiparametric maps was enabled by inferring the data using a pre‐trained SSL‐QALAS model within 10 s. Fast scan‐specific tuning was also demonstrated by fine‐tuning the pre‐trained model with the target subject's data within 15 min.    Conclusion  The proposed SSL‐QALAS method enabled rapid reconstruction of multiparametric maps from 3D‐QALAS measurements without an external dictionary or labeled ground‐truth training data.

SSL‐QALAS : Self‐Supervised Learning for rapid multiparameter estimation in quantitative MRI using 3D‐QALAS