Open AccessOn the role of metal cations in cellular adhesion: Cation specificity
Author(s) -
Armstrong Peter B.,
Jones Daniel P.
Publication year - 1968
Publication title -
journal of experimental zoology
Language(s) - English
Resource type - Journals
eISSN - 1097-010X
pISSN - 0022-104X
DOI - 10.1002/jez.1401670303
Subject(s) - embryo , divalent , amphibian , dissociation (chemistry) , chemistry , rana , spinal cord , alkaline earth metal , adhesion , divalent metal , biophysics , metal , microbiology and biotechnology , anatomy , biology , neuroscience , organic chemistry , ecology
Of the four common alkaline earth cations, only Ca ++ is able to protect Rana pipiens embryos from dissociation of the epidermis into isolated cells by EDTA. Presumably this is because only Ca ++ is able to satisfy the divalent cation requirement for cellular adhesion in this tissue. Although early stage embryos are completely dissociable by EDTA, the axial musculature, brain and spinal cord become resistant to dissociation by stage 17. Tetraphenyl boron is also effective in disaggregating amphibian embryo tissues.
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