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Redistribution of CD8 + T cell subsets in metastatic renal cell carcinoma patients treated with anti‐PD ‐1 therapy
Author(s) -
De Biasi Sara,
Guida Annalisa,
Lo Tartaro Domenico,
Fanelli Martina,
Depenni Roberta,
Dominici Massimo,
Finak Greg,
Porta Camillo,
Paolini Annamaria,
Borella Rebecca,
Bertoldi Carlo,
Cossarizza Andrea,
Sabbatini Roberto,
Gibellini Lara
Publication year - 2022
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.24562
Subject(s) - renal cell carcinoma , cd8 , medicine , cell , t cell , cancer research , kidney , immune system , redistribution (election) , cell therapy , targeted therapy , kidney cancer , oncology , immunology , chemistry , cancer , biochemistry , politics , political science , law
Renal‐cell carcinoma (RCC) is responsible for the majority of tumors arising from the kidney parenchyma. Although a progressive improvement in median overall survival has been observed after the introduction of anti‐PD‐1 therapy, many patients do not benefit from this treatment. Therefore, we have investigated T cell dynamics to find immune modification induced by anti‐PD‐1 therapy. Here, we show that, after therapy, RCC patients (5 responders and 14 nonresponders) are characterized by a redistribution of different subsets across the memory T cell compartment.