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From Coiled Flow Inverter to Stirred Tank Reactor – Bioprocess Development and Ontology Design
Author(s) -
Grühn Julia,
Behr Alexander S.,
Eroglu Talha H.,
Trögel Valentin,
Rosenthal Katrin,
Kockmann Norbert
Publication year - 2022
Publication title -
chemie ingenieur technik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 36
eISSN - 1522-2640
pISSN - 0009-286X
DOI - 10.1002/cite.202100177
Subject(s) - bioprocess , continuous stirred tank reactor , bioreactor , process (computing) , process engineering , inverter , flow (mathematics) , computer science , continuous flow , ontology , key (lock) , biochemical engineering , development (topology) , engineering , chemistry , mathematics , chemical engineering , philosophy , electrical engineering , organic chemistry , epistemology , voltage , operating system , mathematical analysis , geometry , computer security
Abstract Miniaturized bioreactors, such as the coiled flow inverter (CFI), offer several benefits within process development such as lower time and cost factors. In this study, we demonstrate continuous flow experiments in a CFI and transferred them to experiments in a batch reactor by using the oxygen transfer coefficient k L a as a key parameter. In order to simplify the parameter transfer and at the same time develop a basis for future data handling according to the FAIR data principles, an equipment and process ontology was developed for these examples.