Open AccessModels of Inflammation: Carrageenan Air Pouch
Author(s) -
Duarte Djane B.,
Vasko Michael R.,
Fehrenbacher Jill C.
Publication year - 2012
Publication title -
current protocols in pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 26
eISSN - 1934-8290
pISSN - 1934-8282
DOI - 10.1002/0471141755.ph0506s56
Subject(s) - inflammation , pouch , in vivo , carrageenan , exudate , infiltration (hvac) , inflammatory response , chemistry , oxidative stress , immunology , medicine , pathology , biology , biochemistry , surgery , materials science , microbiology and biotechnology , composite material
The subcutaneous air pouch is an in vivo model that can be used to study acute and chronic inflammation, the resolution of the inflammatory response, and the oxidative stress response. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this unit has been extensively used to identify potential anti‐inflammatory drugs. Curr. Protoc. Pharmacol . 56:5.6.1‐5.6.8. © 2012 by John Wiley & Sons, Inc.
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