Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival | Zendy

Jayant S. Vaidya | Zendy; Max Bulsara | Zendy; Christobel Saunders | Zendy; Henrik Flyger | Zendy; Jeffrey Tobias | Zendy; Tammy Corica | Zendy; Samuele Massarut | Zendy; Frederik Wenz | Zendy; Steffi Pigorsch | Zendy; Michael Alvarado | Zendy; Michael Douek | Zendy; W. Eiermann | Zendy; Chris BrewGraves | Zendy; Norman Williams | Zendy; Ingrid Potyka | Zendy; Nicholas Roberts | Zendy; Marcelle Bernstein | Zendy; Douglas Brown | Zendy; Elena Sperk | Zendy; Siobhan Laws | Zendy; Marc Sütterlin | Zendy; Steinar Lundgren | Zendy; Dennis R. Holmes | Zendy; Lorenzo Vinante | Zendy; Fernando A. Bozza | Zendy; Montserrat Pazos | Zendy; Magali Le BlancOnfroy | Zendy; Günther Gruber | Zendy; Wojciech Polkowski | Zendy; Konstantin J. Dedes | Zendy; Marcus Niewald | Zendy; JensUwe Blohmer | Zendy; David R. McCready | Zendy; Richard Hoefer | Zendy; Pond R. Kelemen | Zendy; Gloria Petralia | Zendy; Mary Falzon | Zendy; Michael Baum | Zendy; David Joseph | Zendy

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Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival

Author(s) -

Jayant S. Vaidya,

Max Bulsara,

Christobel Saunders,

Henrik Flyger,

Jeffrey Tobias,

Tammy Corica,

Samuele Massarut,

Frederik Wenz,

Steffi Pigorsch,

Michael Alvarado,

Michael Douek,

W. Eiermann,

Chris BrewGraves,

Norman Williams,

Ingrid Potyka,

Nicholas Roberts,

Marcelle Bernstein,

Douglas Brown,

Elena Sperk,

Siobhan Laws,

Marc Sütterlin,

Steinar Lundgren,

Dennis R. Holmes,

Lorenzo Vinante,

Fernando A. Bozza,

Montserrat Pazos,

Magali Le BlancOnfroy,

Günther Gruber,

Wojciech Polkowski,

Konstantin J. Dedes,

Marcus Niewald,

JensUwe Blohmer,

David R. McCready,

Richard Hoefer,

Pond R. Kelemen,

Gloria Petralia,

Mary Falzon,

Michael Baum,

David Joseph

Publication year - 2020

Publication title -

jama oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.846

H-Index - 99

eISSN - 2374-2445

pISSN - 2374-2437

DOI - 10.1001/jamaoncol.2020.0249

Subject(s) - medicine , lumpectomy , radiation therapy , mastectomy , breast cancer , randomized controlled trial , external beam radiotherapy , surgery , intraoperative radiotherapy , cancer , radiology , brachytherapy

Key Points Question For early breast cancer, is 5-year local control with delayed second-procedure targeted intraoperative radiotherapy (TARGIT-IORT) noninferior to whole-breast postoperative external beam radiotherapy (EBRT), and how do long-term outcomes compare? Findings In this randomized clinical trial including 1153 participants, delayed second-procedure TARGIT-IORT was not noninferior to EBRT at 5-year complete follow-up; however, long-term (median 9 years) mastectomy-free survival, distant disease-free survival, and overall survival were not different. Meaning For early breast cancer, delayed second-procedure single-dose TARGIT-IORT given by reopening the lumpectomy wound had similar long-term mastectomy-free and overall survival compared with EBRT despite higher local recurrence.

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