Open AccessEffect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma
Author(s) -
Rolf D. Issels,
Lars H. Lindner,
Jaap Verweij,
Rüdiger Wessalowski,
Peter Reichardt,
Peter Wust,
Pirus Ghadjar,
Peter Hohenberger,
Martin K. Angele,
Christoph Salat,
Željko Vujašković,
Soeren Daugaard,
Olav Mella,
Ulrich Mansmann,
Hans Roland Dürr,
Thomas Knösel,
Sultan Abdel-Rahman,
M. Schmidt,
Wolfgang Hiddemann,
KarlWalter Jauch,
Claus Belka,
Alessandro Gronchi
Publication year - 2018
Publication title -
jama oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.846
H-Index - 99
eISSN - 2374-2445
pISSN - 2374-2437
DOI - 10.1001/jamaoncol.2017.4996
Subject(s) - medicine , ifosfamide , soft tissue sarcoma , etoposide , anthracycline , sarcoma , surgery , chemotherapy , clinical endpoint , neoadjuvant therapy , randomized controlled trial , oncology , cancer , breast cancer , soft tissue , pathology
Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal local treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes.
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