Open AccessGenetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva
Author(s) -
Brooke E. Howitt,
Heather H. Sun,
Margaretha G.M. Roemer,
Alyssa Kelley,
Bjoern Chapuy,
Emeline Aviki,
Christine J. Pak,
Courtney Connelly,
Evisa Gjini,
Yunling Shi,
Larissa J. Lee,
Akila N. Viswanathan,
Neil S. Horowitz,
Doneuberg,
Christopher P. Crum,
Neal Lindeman,
Frank C. Kuo,
Azra H. Ligon,
Gordon J. Freeman,
F. Stephen Hodi,
Margaret A. Shipp,
Scott J. Rodig
Publication year - 2016
Publication title -
jama oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.846
H-Index - 99
eISSN - 2374-2445
pISSN - 2374-2437
DOI - 10.1001/jamaoncol.2015.6326
Subject(s) - medicine , immunohistochemistry , cervix , polysomy , pathology , vulva , fluorescence in situ hybridization , population , biopsy , cancer research , cancer , chromosome , biology , gene , environmental health , biochemistry
Patients with squamous cell carcinoma (SCC) of the cervix or vulva have limited therapeutic options, and the potential for immunotherapy for this population has not been evaluated. Recent trials suggest that tumors with a genetic basis for PD-1 (programmed cell death protein 1) ligand expression are highly sensitive to therapeutic antibodies targeting PD-1.
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