Open AccessEffect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia
Author(s) -
ChiehHsin Lin,
Ping-Kun Chen,
ShiHeng Wang,
HsienYuan Lane
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.6156
Subject(s) - dementia , placebo , randomized controlled trial , medicine , alzheimer's disease , psychology , psychiatry , disease , pathology , alternative medicine
Key Points Question Is there a gender difference in the effectiveness of benzoate treatment for dementia with behavioral and psychological symptoms? Findings In this post hoc secondary analysis of a randomized, double-masked, 6-week trial that included 97 patients with behavioral and psychological symptoms, benzoate significantly surpassed placebo in cognitive performance in women but not in men on 1 of 2 assessment measures. Benzoate also increased estradiol to follicle-stimulating hormone ratios among women. Meaning These findings suggest that benzoate may improve cognitive function in women with later-phase dementia.
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