Open AccessAssociation Between Donor-Recipient Biological Relationship and Allograft Outcomes After Living Donor Kidney Transplant
Author(s) -
S. Ali Husain,
Kristen L. King,
Navin Sanichar,
R. John Crew,
Jesse D. Schold,
Sumit Mohan
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.5718
Subject(s) - medicine , kidney transplant , association (psychology) , kidney transplantation , kidney , psychology , psychotherapist
Key Points Question What is the association between donor-recipient biological relationship and outcomes after living donor kidney transplantation? Findings In this cohort study including more than 70 000 transplants, after taking donor, recipient, and immunologic factors into account, transplants from donors who were biologically related to their recipients had a higher rate of allograft failure compared with transplants from unrelated donors. Meaning These findings suggest that kidney donors who are related to their recipients may share genetic or socioenvironmental predispositions to kidney disease that shorten allograft longevity.
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