Open AccessFactors Associated With Household Transmission of SARS-CoV-2
Author(s) -
Zachary J. Madewell,
Yang Yang,
Ira M. Longini,
M. Elizabeth Halloran,
Natalie E. Dean
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.22240
Subject(s) - transmission (telecommunications) , covid-19 , medicine , data extraction , demography , medline , computer science , biology , telecommunications , infectious disease (medical specialty) , sociology , disease , biochemistry
Key Points Question Are early estimates of household transmission of SARS-CoV-2 indicative of current household transmission? Findings In this updated systematic review and meta-analysis of 87 studies representing 1 249 163 household contacts from 30 countries, the estimated household secondary attack rate was 19%. An increase in household transmission was observed over time, perhaps owing to improved diagnostic procedures and tools, longer follow-up, more contagious variants, and different study locations. Meaning These findings suggest that the household remains an important site of SARS-CoV-2 transmission, and recent studies have generated higher household secondary attack rate estimates compared with the earliest reports; more transmissible variants and vaccines may be associated with additional changes in the future.
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