Open AccessAssessment of the Diagnostic Efficiency of a Liquid Biopsy Assay for Early Detection of Gastric Cancer
Author(s) -
Daisuke Izumi,
Zhongxu Zhu,
Yuetong Chen,
Shusuke Toden,
Xinying Huo,
Mitsuro Kanda,
Takatsugu Ishimoto,
Dongying Gu,
Miaomiao Tan,
Yasuhiro Kodera,
Hideo Baba,
Wei Li,
Jinfei Chen,
Xin Wang,
Ajay Goel
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.21129
Subject(s) - retrospective cohort study , medicine , biomarker , prospective cohort study , oncology , biopsy , cancer , biology , biochemistry
Key Points Question Can circulating microRNAs be used to derive clinically significant noninvasive diagnostic biomarkers for gastric cancer? Findings This diagnostic study used a multistep and comprehensive biomarker discovery approach to establish a novel, noninvasive, microRNA-based signature for the early detection of gastric cancer, which was retrospectively and prospectively validated in multicenter patient cohorts. Meaning For patients with gastric cancer and individuals with a high risk for gastric cancer, a microRNA-based signature may improve the early detection of gastric cancer.
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