Open AccessAssessment of Magnetic Resonance Imaging Changes and Functional Outcomes Among Adults With Severe Herpes Simplex Encephalitis
Author(s) -
Benjamine Sarton,
Pierre Jaquet,
Djida Belkacemi,
Étienne de Montmollin,
Fabrice Bonneville,
Charline Sazio,
Aurélien Frerou,
Marie Conrad,
Delphine Daubin,
Russell Chabanne,
Laurent Argaud,
Frédéric Dailler,
N. Brulé,
Nicolas Lerolle,
Quentin Maestraggi,
Julien Marechal,
Pierre Bailly,
Keyvan Razazi,
François Mateos,
Bertrand Guidet,
Albrice Levrat,
Vincent Susset,
Alexandre Lautrette,
JeanPaul Mira,
Ahmed El Kalioubie,
Alexandre Robert,
Alexandre Massri,
Jean François Albucher,
JeanMarc Olivot,
Jean Marie Conil,
Lila Boudma,
JeanFrançois Timsit,
Romain Sonneville,
Stein Silva,
Pierre Jaquet,
Étienne de Montmollin,
Claire Dupuis,
Mikaël Alves,
Laurent Argaud,
Pierre Bailly,
François Barbier,
Lila Bouadma,
N. Brulé,
Fabrice Brunel,
Russell Chabanne,
Marie Conrad,
Daniel Silva,
Frédéric Dailler,
Delphine Daubin,
Sophie Demeret,
Nicolas Lerolle,
Julien Marechal,
Bruno Mourvillier,
Ahmed El Kalioubi,
Benjamine Sarton,
Stein Silva,
Romain Sonneville,
Vincent Susset,
JeanMarc Tadié,
J. Timsit,
Michel Wolff,
Alexandre Lautrette,
Emmanuel Novy,
Bertrand Guidet,
François Mateos,
C. Brault,
Quentin Maestraggi,
Keyvan Razazi,
JeanPierre Quenot,
Aurélie Joret,
Albrice Levrat,
Alexandre Massri,
Alexandre Robert,
Damien Contou,
JeanPaul Mira,
Stéphane Gaudry,
Guillaume Voiriot,
Asael Berger,
Vincent Das,
Nicolas Engrand,
Martin Murgier,
Shidasp Siami,
Sami Hraiech,
Éric Mariotte,
Claire Ragot,
Annabelle Stoclin,
Pierre Trouiller,
Mathieu Schmidt,
Charline Sazio
Publication year - 2021
Publication title -
jama network open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.278
H-Index - 39
ISSN - 2574-3805
DOI - 10.1001/jamanetworkopen.2021.14328
Subject(s) - medicine , interquartile range , glasgow coma scale , magnetic resonance imaging , intensive care unit , modified rankin scale , logistic regression , cohort , cohort study , retrospective cohort study , surgery , radiology , ischemia , ischemic stroke
Key Points Question Are early brain changes seen on magnetic resonance imaging (MRI) associated with functional outcomes among adult patients with severe herpes simplex encephalitis (HSE)? Findings In adult patients with HSE, extensive brain changes seen on MRI during the first month after intensive care unit admission were independently associated with poor functional outcome at 90 days. Thalamic diffusion signal changes were frequently observed and were associated with poor prognosis, mainly in older patients. Meanings These findings suggest that, among adult patients with severe HSE, early MRI data were associated with neurological outcomes, both in terms of brain lesion extension and critical focal MRI signal changes.
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