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Key Points   Question  What is the association of contrast volume used during percutaneous coronary intervention with the risk of acute kidney injury?    Findings  In this prognostic study of nearly 3 million adults undergoing percutaneous coronary intervention, a predictive model for the association of contrast volume with the risk of acute kidney injury was developed and validated. The association was nonlinear along the spectrum of contrast volume and varied according to patient baseline risk.    Meaning  This model could support personalized approaches that consider the complex association between contrast volume and the risk of acute kidney injury when determining contrast dosing during interventional procedures.

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Development and Validation of a Model for Predicting the Risk of Acute Kidney Injury Associated With Contrast Volume Levels During Percutaneous Coronary Intervention