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Elevations in parathyroid hormone (PTH) level have been associated with adverse clinical outcomes, including cardiovascular disease and mortality.1,2 Loop diuretics have been linked to increased PTH levels in patients with chronic kidney disease (CKD),3,4 but this association has not been investigated in the general population. We used data from the National Health and Nutrition Examination Survey (NHANES)5,6 to test the hypothesis that loop diuretic use associates with elevated PTH in adults with preserved renal function.

Association of Loop Diuretic Use With Higher Parathyroid Hormone Levels in Patients With Normal Renal Function