Open AccessThe Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers
Author(s) -
Carolyn Y. Ho,
Sharlene M. Day,
Steven D. Colan,
Mark W. Russell,
Jeffrey A. Towbin,
Mark V. Sherrid,
Charles E. Canter,
John L. Jefferies,
Anne M. Murphy,
Allison L. Cirino,
Theodore P. Abraham,
Matthew R.G. Taylor,
Luisa Mestroni,
David A. Bluemke,
Petr Jarolı́m,
Ling Shi,
Lynn A. Sleeper,
Christine E. Seidman,
E. John Orav,
for the HCMNet Investigators
Publication year - 2017
Publication title -
jama cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.108
H-Index - 63
eISSN - 2380-6591
pISSN - 2380-6583
DOI - 10.1001/jamacardio.2016.5670
Subject(s) - medicine , hypertrophic cardiomyopathy , phenotype , cardiomyopathy , mutation , cardiology , heart failure , genetics , gene , biology
Sarcomere mutations and left ventricular (LV) hypertrophy (LVH) are cardinal features of hypertrophic cardiomyopathy (HCM). However, little is known about the full spectrum of phenotypic manifestations or how LVH influences disease expression.
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