Open AccessDiscordant Aortic Valve Morphology in Monozygotic Twins
Author(s) -
Dawn S. Hui,
Robert O. Bonow,
Joshua M. Stolker,
Stephen R. Braddock,
Richard Lee
Publication year - 2016
Publication title -
jama cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.108
H-Index - 63
eISSN - 2380-6591
pISSN - 2380-6583
DOI - 10.1001/jamacardio.2016.2522
Subject(s) - medicine , bicuspid aortic valve , monozygotic twin , thoracic aortic aneurysm , aortic valve , exome sequencing , aortic aneurysm , aneurysm , cardiology , surgery , genetics , gene , mutation , biology
Bicuspid aortic valve (BAV) is considered an autosomal dominant condition, which is commonly associated with thoracic aortic aneurysm. Both conditions pose the risk of valvular and aortic complications not only for affected patients but also for genetically related persons as well. The genetic underpinnings of these disease processes, which are in various stages of elucidation, have implications for screening and risk prognostication.
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