Open AccessAssociation of Genetic Variations With Nonfatal Venous Thrombosis in Postmenopausal Women
Author(s) -
Nicholas L. Smith,
Lucia A. Hindorff,
Susan R. Heckbert,
Rozenn N. Lemaître,
Kristin D. Marciante,
Kenneth Rice,
Thomas Lumley,
Joshua C. Bis,
Kerri L. Wiggins,
Frits R. Rosendaal,
Bruce M. Psaty
Publication year - 2007
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.297.5.489
Subject(s) - medicine , single nucleotide polymorphism , venous thrombosis , fibrinolysis , haplotype , genetic variation , candidate gene , population , fibrinogen , bioinformatics , thrombosis , genetics , allele , gene , genotype , biology , environmental health
Although the roles of clotting proteins and enzymes that activate or inhibit fibrin production and lysis are well characterized, the underlying contribution of genetic variation in these constituents to risk of venous thrombosis (VT) has not been fully investigated.
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