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The accurate identification and interpretation of germline mutations in mismatch repair genes in colorectal cancer cases is critical for clinical management. Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when conventional DNA sequencing alone is used.

Conversion Analysis for Mutation Detection in <EMPH>MLH1</EMPH> and <EMPH>MSH2</EMPH> in Patients With Colorectal Cancer