Open AccessAssociation Between the T29→C Polymorphism in the Transforming Growth Factor β1 Gene and Breast Cancer Among Elderly White Women
Author(s) -
Elad Ziv,
Jane A. Cauley,
Phillip A. Morin,
Robert Saiz,
W S Browner
Publication year - 2001
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.285.22.2859
Subject(s) - medicine , breast cancer , oncology , white (mutation) , polymorphism (computer science) , association (psychology) , transforming growth factor , gene , genetics , allele , gynecology , cancer , biology , philosophy , epistemology
Transgenic animal experiments suggest that increased expression of transforming growth factor beta1 (TGF-beta1) is protective against early tumor development, particularly in breast cancer. A T-->C (thymine to cytosine) transition in the 29th nucleotide in the coding sequence results in a leucine to proline substitution at the 10th amino acid and is associated with increased serum levels of TGF-beta1.
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