Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance | Zendy

Patrick N. A. Harris | Zendy; Paul Anantharajah Tambyah | Zendy; David Chien Lye | Zendy; Yin Mo | Zendy; Tau H. Lee | Zendy; Mesut Yılmaz | Zendy; Thamer H. Alenazi | Zendy; Yaseen M. Arabi | Zendy; Marco Falcone | Zendy; Matteo Bassetti | Zendy; Elda Righi | Zendy; Benjamin A. Rogers | Zendy; Souha S. Kanj | Zendy; Hasan Bhally | Zendy; Jonathan R. Iredell | Zendy; Marc Mendelson | Zendy; Tom Boyles | Zendy; David Looke | Zendy; Spiros Miyakis | Zendy; Genevieve Walls | Zendy; Mohammed Al Khamis | Zendy; Ahmed Zikri | Zendy; Amy Crowe | Zendy; Paul R. Ingram | Zendy; Nick Daneman | Zendy; Paul Griffin | Zendy; Eugene Athan | Zendy; Penelope Lorenc | Zendy; Peter Baker | Zendy; Leah W. Roberts | Zendy; Scott A. Beatson | Zendy; Anton Y. Peleg | Zendy; Tiffany HarrisBrown | Zendy; David L. Paterson | Zendy

Open Access

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance

Author(s) -

Patrick N. A. Harris,

Paul Anantharajah Tambyah,

David Chien Lye,

Yin Mo,

Tau H. Lee,

Mesut Yılmaz,

Thamer H. Alenazi,

Yaseen M. Arabi,

Marco Falcone,

Matteo Bassetti,

Elda Righi,

Benjamin A. Rogers,

Souha S. Kanj,

Hasan Bhally,

Jonathan R. Iredell,

Marc Mendelson,

Tom Boyles,

David Looke,

Spiros Miyakis,

Genevieve Walls,

Mohammed Al Khamis,

Ahmed Zikri,

Amy Crowe,

Paul R. Ingram,

Nick Daneman,

Paul Griffin,

Eugene Athan,

Penelope Lorenc,

Peter Baker,

Leah W. Roberts,

Scott A. Beatson,

Anton Y. Peleg,

Tiffany HarrisBrown,

David L. Paterson

Publication year - 2018

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2018.12163

Subject(s) - medicine , meropenem , piperacillin/tazobactam , piperacillin , klebsiella pneumoniae , tazobactam , ceftriaxone , carbapenem , microbiology and biotechnology , antibiotics , antibiotic resistance , escherichia coli , imipenem , biology , genetics , gene , bacteria , pseudomonas aeruginosa , biochemistry

Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae. Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Piperacillin-tazobactam may be an effective "carbapenem-sparing" option to treat extended-spectrum β-lactamase producers.

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