Open AccessInterferon Gamma Levels in the Sinus, Ear, and Airway in a Rabbit Sinusitis Model Induced by Bacteroides Inoculation
Author(s) -
Harumi Jyonouchi,
Sining Sun,
Cynthia A. Kennedy,
Frank L. Rimell
Publication year - 2000
Publication title -
archives of otolaryngology - head and neck surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-361X
pISSN - 0886-4470
DOI - 10.1001/archotol.126.4.529
Subject(s) - maxillary sinus , sinus (botany) , sinusitis , interferon gamma , inoculation , medicine , pathology , microbiology and biotechnology , biology , immunology , anatomy , cytokine , botany , genus
Previously, we found minimal bacterial dissemination and no evidence of systemic inflammation in a rabbit sinusitis model in which the left maxillary sinus was inflamed by Bacteroides inoculation with the ostium closed. However, we observed an increase in anti-Bacteroides IgG antibodies in the contralateral sinus, lower airway, and middle ear, with an apparent increase in interferon gamma (IFN-gamma) messenger RNA expression in the ear and sinus mucosa.
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