Open AccessMitochondrial Damage in the Trabecular Meshwork of Patients With Glaucoma
Author(s) -
Alberto Izzotti
Publication year - 2010
Publication title -
archives of ophthalmology
Language(s) - English
Resource type - Journals
eISSN - 1538-3601
pISSN - 0003-9950
DOI - 10.1001/archophthalmol.2010.87
Subject(s) - trabecular meshwork , mitochondrial dna , glaucoma , mitochondrion , oxidative stress , dna damage , biology , apoptosis , genetics , ophthalmology , medicine , endocrinology , gene , dna
To analyze the frequency of mitochondrial DNA (mtDNA) damage in patients with primary open-angle glaucoma. Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species.
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