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To the Editor: Age-related macular degeneration (AMD) is a leading cause of vision loss. Age-related Eye Disease Study (AREDS) participants reporting highest intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) were approximately half as likely as their peers reporting lowest intake of these nutrients to have neovascular (NV) AMD1 at baseline or to progress across a six year period from bilateral drusen to central geographic atrophy (CGA).2 AREDS provides data that represent, to our knowledge, the largest longitudinal sample collected and classified with standardized methods as part of a natural history study on AMD. We now report that our baseline and six-year findings persisted in 12-year AMD incidence models. These results are consistent with existing data.3,7

ω-3 Long-Chain Polyunsaturated Fatty Acid Intake Inversely Associated With 12-Year Progression to Advanced Age-Related Macular Degeneration