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We recently reported that acute retinal necrosis in humans develops in a setting where delayed hypersensitivity (DH) to the varicella-zoster virus (VZV) antigen was absent, implying that virus-specific DH mitigates against acute retinal necrosis.

A Relationship Between Varicella-Zoster Virus–Specific Delayed Hypersensitivity and Varicella-Zoster Virus–Induced Anterior Uveitis