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There is increasing evidence that reduced ocular blood flow plays a role in the pathogenesis of glaucoma. In patients with normal-tension glaucoma, ocular blood flow abnormalities may be associated with dysfunction of the endothelin 1 (ET-1) regulation system.

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl