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Excellent long-term prognosis of penetrating corneal grafts has been explained by the immunological privilege of the cornea and the anterior chamber. In animal models the secretion of transforming growth factor beta(2) (TGF-beta(2)) into the anterior chamber and the expression of the Fas ligand on corneal endothelial cells were identified as important for the integrity of the immunological privilege.

Soluble Fas Ligand and Transforming Growth Factor β2 in the Aqueous Humor of Patients With Endothelial Immune Reactions After Penetrating Keratoplasty