Open AccessPrediction of Longitudinal Brain Atrophy in Multiple Sclerosis by Gray Matter Magnetic Resonance Imaging T2 Hypointensity
Author(s) -
Robert Bermel,
Srinivas R. Puli,
Richard A. Rudick,
Bianca WeinstockGuttman,
Elizabeth Fisher,
Frederick Munschauer,
Rohit Bakshi
Publication year - 2005
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.62.9.1371
Subject(s) - medicine , atrophy , magnetic resonance imaging , multiple sclerosis , interferon beta 1a , placebo , pathology , radiology , immunology , alternative medicine , interferon beta
Gray matter magnetic resonance imaging T2 hypointensity, a marker of iron deposition, is associated with clinical impairment and brain atrophy in cross-sectional studies of multiple sclerosis. Treatment with intramuscular interferon beta-1a limits brain atrophy in the second year of treatment.
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