Open AccessSex, Apolipoprotein E ε4 Status, and Hippocampal Volume in Mild Cognitive Impairment
Author(s) -
Adam Fleisher,
Michael Grundman,
Clifford R. Jack,
Ronald C. Petersen,
Catherine L. Taylor,
Hyun T. Kim,
Denise H. B. Schiller,
Victor P. Bagwell,
Drahomira Sencakova,
Myron Weiner,
Charles DeCarli,
Steven T. DeKosky,
Christopher H. van Dyck,
Leon J. Thal
Publication year - 2005
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.62.6.953
Subject(s) - apolipoprotein e , hippocampal formation , psychology , medicine , alzheimer's disease , allele , atrophy , hippocampus , dementia , audiology , endocrinology , disease , biology , genetics , gene
Subjects with mild cognitive impairment (MCI) have been shown to have reduced hippocampal volumes relative to normal elderly control subjects. The presence of the apolipoprotein E epsilon4 (APOE*E4) allele has been associated with greater hippocampal atrophy in women than in men with Alzheimer disease. This relationship has not been demonstrated in MCI.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom