Open AccessChallenging the Clinical Utility of the 14-3-3 Protein for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease
Author(s) -
Michael D. Geschwind,
Jennifer L. Martindale,
Deborah Miller,
Stephen J. DeArmond,
Jane UyeharaLock,
David A. Gaskin,
Joel H. Kramer,
Nicholas M. Barbaro,
Bruce L. Miller
Publication year - 2003
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.60.6.813
Subject(s) - medicine , pathological , cerebrospinal fluid , disease , context (archaeology) , lumbar puncture , pathology , autopsy , creutzfeldt jakob syndrome , prion protein , paleontology , biology
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative disorder for which there is no noninvasive and disease-specific test for premortem diagnosis. Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD.
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