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Prurigo nodularis (PN) presents with excoriated nodules on the extensor surfaces of limbs and trunk. It is commonly seen in persons infected with human immunodeficiency virus (HIV) and with low CD4 counts.1 The pathogenesis of PN is not well understood, but it may be related to inflammatory mediators.2–4 Interestingly, combination therapy that includes raltegravir, an integrase inhibitor that prevents viral DNA insertion into host cell DNA, has been noted to rapidly reduce viral load to levels comparable to or lower than other HIV antiretroviral therapies (ARTs).5,6 We report 2 cases of PN that dramatically improved within 2 weeks of initiating twice daily oral dosing with raltegravir, 400 mg.

Persistent Prurigo Nodularis Responsive to Initiation of Combination Therapy With Raltegravir