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Langerhans cell histiocytosis (LCH) is a rare disease with a peak incidence in childhood. There is limited experience with treatment options for adult patients having multisystemic LCH involvement. We report successful treatment of a 70-year-old woman with adult onset of LCH and multisystem disease (diabetes insipidus centralis, bone marrow infiltration, and lung and skin involvement).

Successful Treatment of Adult Multisystemic Langerhans Cell Histiocytosis With Psoralen–UV-A, Prednisolone, Mercaptopurine, and Vinblastine