English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A 59-year-old human immunodeficiency virus-1–positive (HIV-1+) white man presented with a nonhealing area that extended extensively around the perianal skin and up into the anal canal. The area had been present for greater than 2 years with an increase in size over the past 6 months. Biopsies were performed, and multiple biopsy specimens sampled from the cutaneous surface as well as within the distal anal canal showed squamous cell carcinoma in situ. Thepatient’sHIV-1diseasehadbeendiagnosedapproximately 15 years earlier, and had been well controlled during most of that time with antiviral therapy, including protease inhibitorsover thepast4years.Thepatient’sCD4cell count was more than 500/μL, and he had an unmeasurable viral load;hehadbeentakingstavudine(40mgtwicedaily), lamivudine (150 mg twice daily), indinavir (400 mg twice daily), and nelfinavir (250 mg 3 times per day) for approximately 1 year. Other significant medical history included 5 basal cell carcinomas, both nodular and superficial types, dating from 1990, with the last tumor treated in 1996. Physical examination revealed an area of perianal erythema with extensive areas of ulceration around the rectum and extending into the rectum (Figure 1). Anoscopic examination showed that the area of visually atypical anal mucosa extended just inside the anal canal. Multiple biopsies were performed on the involved skin, including the mucosa, to better define the extent of disease.

Imiquimod and 5% Fluorouracil Therapy for Anal and Perianal SquamousCell Carcinoma In Situ in an HIV-1–Positive Man