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We discuss Fermi observations of gamma-ray loud binaries. We show that withinhadronic model of activity of LSI +61 303, detection of cut-off in the GeVspectrum constrains maximal energy of the primary protons. In this way, the GeVgamma-ray data impose constraint on the expected neutrino signal (spectrum andlightcurve) from the source. We also briefly discuss perspectives of GeV banddetection of PSR B1259-63 during the 2010 periastron passage.

Study of gamma-ray loud binaries in the Fermi era