English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

We report the simultaneous characterization of time- and force-dependentmechanical properties of adherent cells in the physiologically relevant regimeof large forces. We used magnetic tweezers to apply forces to magnetic beadsbound to the cytoskeleton, and recorded the resulting deformation (creepresponse). The creep response followed a weak power law at all force levels.Stress stiffening and fluidization occurred simultaneously and were quantifiedby the force-dependence of the creep compliance and the power law exponent. Theamount of stiffening and fluidization in response to force was controlledsolely by the contractile prestress of the cell and followed a simplerelationship. This behavior may be of fundamental importance in biologicalprocesses that involve a mechanical interaction between cells and theirenvironment.

Contractile prestress controls stiffening and fluidization of living cells in response to large external forces