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A method for the quantitative assessment of spatio-temporal structuring ofbrain activity is presented. This approach is employed in a longitudinal casestudy of a child with frontal lobe epilepsy (FLE) and tested against anage-matched control group. Several correlation measures that are sensitive tolinear and/or non-linear relations in multichannel scalp EEG are combined withan hierarchical cluster algorithm. Beside a quantitative description of theoverall degree of synchronization the spatial relations are investigated bymeans of the cluster characteristics. The chosen information measures not onlydemonstrate their suitability in the characterization of the ictal andinterictal phases but they also follow the course of delayed recovery of thepsychiatric symptomatology during successful medication. The results based onthis single case study suggest testing this approach for quantitative controlof therapy in an extended clinical trial.

Spatio-Temporal Structuring of Brain Activity - Description of Interictal EEG in Paediatric Frontal Lobe Epilepsy